Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20101123 | 0.88 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL19253768 | 0.79 | PIK3CD (0.62) | KMT2AMAPTALDH1A1LMNAPKM | |
| SCHEMBL19253710 | 0.74 | RAB9A (0.47) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL19253774 | 0.74 | LRRK2 (0.61) | MEN1KMT2AMAPTKDM4ERAB9A | |
| SCHEMBL19253737 | 0.74 | LRRK2 (0.44) | MEN1KMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL2116732 | 0.73 | KDM4E (0.64) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL19303109 | 0.73 | ABL1 (0.41) | PIK3CAABL1DYRK1ACYP3A4CYP2D6 | |
| SCHEMBL19253695 | 0.73 | NPC1 (0.59) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL19253621 | 0.72 | NPC1 (0.42) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL19253766 | 0.72 | CASP3 (0.60) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081612-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ACTAVALON, INC. (US) | 2018-05-03 | — | — | WO | disclosed |