Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446096 | 0.80 | DAPK3 (0.41) | ALDH1A1DAPK3JAK2PRKD3MAP4K4 | |
| SCHEMBL26301302 | 0.79 | DAPK3 (0.35) | ALDH1A1POLBKMT2ADAPK3JAK2 | |
| SCHEMBL20101951 | 0.78 | ALDH1A1 (0.39) | ALDH1A1POLBKMT2ADAPK3JAK2 | |
| SCHEMBL4247977 | 0.75 | ABL1 (0.40) | ALDH1A1POLBKMT2ADAPK3JAK2 | |
| SCHEMBL13731286 | 0.75 | DAPK3 (0.40) | ALDH1A1KMT2ADAPK3JAK2PRKD3 | |
| SCHEMBL14451934 | 0.74 | ATM (0.38) | ALDH1A1POLBDAPK3JAK2PRKD3 | |
| Hydrochloric Acid SCHEMBL1396143 | 0.74 | ABL1 (0.39) | ALDH1A1POLBKMT2ADAPK3JAK2 | |
| Ethane SCHEMBL15559374 | 0.72 | ABL1 (0.38) | ALDH1A1KMT2ADAPK3JAK2PRKD3 | |
| SCHEMBL4050384 | 0.71 | ALDH1A1 (0.39) | ALDH1A1KMT2AABL1GAAATM | |
| SCHEMBL21048180 | 0.71 | HPGD (0.51) | ALDH1A1POLBKMT2AMAPK8GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | ALDH1A1 1319/4885POLB 439/4885KMT2A 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.