SCHEMBL2010214

SCHEMBL2010214

C[C@H]1CN(Cc2ccc(-c3cccnc3N3CCC(Nc4ccc(F)cc4)CC3)nc2)CCN1C(=O)OCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MLNR O43193 14/20 0.46
CYP3A4 P08684 3/20 0.45
CYP2D6 P10635 1/20 0.45
GHSR Q92847 1/20 0.45
HDAC1 Q13547 2/20 0.40
HDAC3 O15379 1/20 0.40
CYP2C9 P11712 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40
MAPKAPK3 Q16644 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
PDK1 Q15118 1/20 0.39
PDK2 Q15119 1/20 0.39
PDK3 Q15120 1/20 0.39
PDK4 Q16654 1/20 0.39
CHRM4 P08173 1/20 0.39
CCR1 P32246 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3134470 0.90 MLNR (0.50) MLNRCYP3A4CYP2D6GHSRCCR1
SCHEMBL2011342 0.90 MLNR (0.45) MLNRCYP3A4CYP2D6GHSRCYP2C9
SCHEMBL2009575 0.85 HDAC1 (0.42) HDAC1HDAC3CYP2C9SLC6A4SLC6A3
SCHEMBL2012686 0.82 HDAC1 (0.40) HDAC1HDAC3CYP2C9SLC6A4SLC6A3
SCHEMBL2010299 0.80 MLNR (0.68) MLNRCYP3A4CYP2D6GHSR
SCHEMBL2013240 0.80 MLNR (0.69) MLNRCYP3A4CYP2D6GHSR
Hydrochloric Acid SCHEMBL2003648 0.79 MLNR (0.68) MLNRCYP3A4CYP2D6GHSR
SCHEMBL1703977 0.77 MLNR (0.64) MLNRCYP3A4CYP2D6PDK1PDK2
SCHEMBL3138703 0.77 MLNR (0.53) MLNRCYP3A4CYP2D6GHSR
Hydrochloric Acid SCHEMBL2008327 0.76 MLNR (0.52) MLNRCYP3A4CYP2D6GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964602-B2 Biaryl compounds useful as agonists of the Gpr38 receptor GLAXO GROUP LIMITED (GB) 2011-06-21 US disclosed