Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL79116 | 0.79 | GRM5 (0.49) | GRM5CA12CA2CA9CA1 | |
| SCHEMBL31236140 | 0.79 | ABL1 (0.42) | GRM5CA12CA2CA9CA1 | |
| SCHEMBL22492744 | 0.79 | ABL1 (0.42) | GRM5CA12CA2CA9CA1 | |
| SCHEMBL26988477 | 0.79 | GRM5 (0.44) | GRM5ALDH1A1CACNA2D1CACNB2CACNA1C | |
| SCHEMBL30283030 | 0.77 | APP (0.44) | CA12CA2CA9CA1ABL1 | |
| SCHEMBL16346233 | 0.77 | ACACB (0.50) | GRM5ALDH1A1ALK | |
| SCHEMBL31387703 | 0.77 | APP (0.48) | GRM5FFAR1ALDH1A1LMNACYP3A4 | |
| SCHEMBL718295 | 0.76 | CA12 (0.60) | GRM5CA12CA2CA9CA1 | |
| SCHEMBL2798077 | 0.73 | ALDH1A1 (0.50) | ALDH1A1LMNACYP3A4HSD17B10HTR2B | |
| SCHEMBL2814308 | 0.72 | CA12 (0.49) | GRM5CA12CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111278818-B | BTK inhibitor compounds | 伊莱利利公司 | 2023-03-28 | — | — | CN | disclosed |
| US-11542249-B2 | BTK inhibitor compounds | ELI LILLY AND COMPANY (US) | 2023-01-03 | — | — | US | disclosed |
| US-11542249-B2 | BTK inhibitor compounds | ELI LILLY AND COMPANY (US) | 2023-01-03 | — | — | US | disclosed |
| EP-3707133-B1 | BTK INHIBITOR COMPOUNDS | LILLY CO ELI (US) | 2021-12-15 | — | — | EP | disclosed |
| US-20200290997-A1 | BTK INHIBITOR COMPOUNDS | ELI LILLY AND COMPANY | 2020-09-17 | — | — | US | disclosed |
| US-20200290997-A1 | BTK INHIBITOR COMPOUNDS | ELI LILLY AND COMPANY | 2020-09-17 | — | — | US | disclosed |
| EP-3707133-A1 | BTK INHIBITOR COMPOUNDS | Eli Lilly and Company (US) | 2020-09-16 | — | — | EP | disclosed |
| CN-111278818-A | BTK inhibitor compounds | 伊莱利利公司 | 2020-06-12 | — | — | CN | disclosed |
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | EUDENDRON S.R.L. (IT) | 2019-07-02 | — | — | US | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | MAP4K2, MAP3K20, MAPKAPK2 | GRM5 971/4885CA12 4578/4885CA2 2696/4885 |
| US-20200290997-A1 | BTK INHIBITOR COMPOUNDS | BTK, SYK, LCK | GRM5 3757/4885CA12 4544/4885CA2 1902/4885 |
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | MAP4K2, MAP3K20, MAPKAPK2 | GRM5 971/4885CA12 4578/4885CA2 2696/4885 |
| US-11542249-B2 | BTK inhibitor compounds | BTK, SYK, LCK | GRM5 3736/4885CA12 4457/4885CA2 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.