Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.74 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | TP53 | P04637 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | STAT1 | P42224 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103018 | 0.90 | KDM4E (0.76) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL25680996 | 0.88 | KDM4E (0.74) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL25681076 | 0.87 | KDM4E (0.71) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL25681170 | 0.80 | KDM4E (0.62) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL16446197 | 0.65 | TNK2 (0.58) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL16445965 | 0.65 | TNK2 (0.58) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL16445963 | 0.65 | TNK2 (0.58) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL20102974 | 0.65 | KDM4E (0.60) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL20102972 | 0.65 | ALDH1A1 (0.74) | KDM4EHPGDHSD17B10NPC1RAB9A | |
| SCHEMBL16445925 | 0.64 | PDE5A (0.72) | KDM4EHSD17B10NPC1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081451-A1 | SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2018-05-03 | — | — | WO | disclosed |