Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 11/20 | 0.55 |
| ▸ | NPC1 | O15118 | 10/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25681055 | 0.91 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL20102972 | 0.90 | ALDH1A1 (0.74) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL25681303 | 0.80 | ALDH1A1 (0.72) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL25681242 | 0.79 | ALDH1A1 (0.69) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL20103018 | 0.74 | KDM4E (0.76) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL31706519 | 0.73 | CYP1A2 (0.54) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL15598872 | 0.72 | CYP2D6 (0.72) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL2189895 | 0.71 | CYP1A2 (0.58) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD | |
| SCHEMBL4089490 | 0.71 | TOP2A (0.63) | ALDH1A1HSD17B10MAPK1TSHRLMNA | |
| SCHEMBL2809356 | 0.71 | GRM1 (0.54) | KDM4EALDH1A1HSD17B10SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230181589-A1 | PRMT5 INHIBITORS FOR OCULAR THERAPY | NATIONAL INSTITUTES OF HEALTH | 2023-06-15 | — | — | US | disclosed |
| US-20230181589-A1 | PRMT5 INHIBITORS FOR OCULAR THERAPY | NATIONAL INSTITUTES OF HEALTH | 2023-06-15 | — | — | US | disclosed |
| US-11034689-B2 | Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200062745-A1 | Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-02-27 | — | — | US | disclosed |
| WO-2018081451-A1 | SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034689-B2 | Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment | PRMT5, PRMT1, PRMT3 | KDM4E 141/4885ALDH1A1 3681/4885HSD17B10 2611/4885 |
| US-20200062745-A1 | Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment | PRMT5, PRMT1, PRMT3 | KDM4E 141/4885ALDH1A1 3681/4885HSD17B10 2611/4885 |
| US-20230181589-A1 | PRMT5 INHIBITORS FOR OCULAR THERAPY | PRMT5, PRMT1, PRMT3 | KDM4E 66/4885ALDH1A1 4366/4885HSD17B10 3917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.