Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.46 |
| ▸ | TNKS | O95271 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103203 | 0.88 | SMYD3 (0.44) | SMYD3GRM5TNKS2TNKSKMT2A | |
| SCHEMBL20103478 | 0.82 | TNKS2 (0.46) | TNKS2TNKSKMT2ACRBNMEN1 | |
| SCHEMBL18208628 | 0.81 | DYRK1A (0.41) | SMYD3KMT2AMEN1GRM4 | |
| SCHEMBL18208139 | 0.81 | MEN1 (0.43) | TNKS2TNKSKMT2AMEN1EGLN1 | |
| SCHEMBL18208142 | 0.81 | MEN1 (0.43) | TNKS2TNKSKMT2AMEN1EGLN1 | |
| SCHEMBL18208630 | 0.81 | DYRK1A (0.41) | SMYD3KMT2AMEN1GRM4 | |
| SCHEMBL18208212 | 0.81 | JAK2 (0.52) | TNKSKDM4EHSD11B1 | |
| SCHEMBL18208215 | 0.81 | JAK2 (0.52) | TNKSKDM4EHSD11B1 | |
| SCHEMBL18208670 | 0.81 | HSD11B1 (0.44) | KMT2AMEN1HSD11B1EGLN1 | |
| SCHEMBL18208672 | 0.81 | HSD11B1 (0.44) | KMT2AMEN1HSD11B1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |