Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 11/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007317 | 0.89 | PTGDR2 (0.73) | PTGDR2PLA2G2APLA2G1BAKR1B1LMNA | |
| SCHEMBL2006672 | 0.87 | PTGDR2 (0.75) | PTGDR2PLA2G2APLA2G1BAKR1B1PTGES | |
| SCHEMBL2004539 | 0.86 | PTGDR2 (0.70) | PTGDR2PLA2G2APLA2G1BAKR1B1 | |
| SCHEMBL2000586 | 0.84 | PTGDR2 (0.76) | PTGDR2PTGS2PLA2G2APLA2G1BAKR1B1 | |
| SCHEMBL2002085 | 0.84 | PTGDR2 (0.70) | PTGDR2AKR1B1PTGESALOX5 | |
| SCHEMBL2001831 | 0.84 | PTGDR2 (0.79) | PTGDR2PLA2G2APLA2G1BAKR1B1MEN1 | |
| SCHEMBL27905712 | 0.84 | PTGDR2 (0.49) | PTGDR2PLA2G2AAKR1B1MEN1ALDH1A1 | |
| SCHEMBL2460905 | 0.83 | PLA2G2A (0.69) | PTGS1PTGS2PLA2G2APLA2G1BMEN1 | |
| SCHEMBL2000681 | 0.82 | PTGDR2 (0.79) | PTGDR2AKR1B1 | |
| SCHEMBL2005637 | 0.81 | PTGDR2 (1.00) | PTGDR2PLA2G2APLA2G1BAKR1B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
| WO-2007022501-A2 | USEFUL INDOLE COMPOUNDS | MICROBIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203209-A1 | Useful indole compounds | TPH2, HRH2, HRH1 | PTGDR2 28/4885PTGS1 159/4885PTGS2 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.