Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | LOX | P28300 | 1/20 | 0.47 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 6/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 2/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10159790 | 0.79 | RECQL (0.57) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL24974311 | 0.75 | RECQL (0.52) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL27731807 | 0.72 | RECQL (0.62) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL1437084 | 0.72 | LOXL2 (0.57) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL7270108 | 0.71 | HSD17B10 (0.55) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL29556838 | 0.71 | HSD17B10 (0.55) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL5285356 | 0.71 | HSD17B10 (0.55) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL30969437 | 0.69 | RECQL (0.53) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL1886874 | 0.69 | RECQL (0.58) | RECQLLOXLOXL3LOXL2EPHX1 | |
| SCHEMBL2092329 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081047-A1 | CYCLOHEXYL GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |