SCHEMBL20105035

SCHEMBL20105035

C=C(C)C(=O)Oc1ccc(CCC(=O)Oc2ccc(-c3ccc(OC(=O)CC)cc3)cc2F)cc1OC(=O)C(=C)C

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 3/20 0.42
KMT2A Q03164 3/20 0.39
MAPT P10636 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
ACLY P53396 1/20 0.35
ESR1 P03372 2/20 0.34
HIF1A Q16665 2/20 0.34
CCR5 P51681 1/20 0.34
S1PR1 P21453 1/20 0.34
S1PR3 Q99500 1/20 0.34
S1PR5 Q9H228 1/20 0.34
AKR1C3 P42330 2/20 0.34
TRPV1 Q8NER1 1/20 0.33
RECQL P46063 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
AKR1C2 P52895 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16803375 0.94 KMT2A (0.39) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL18541168 0.90 KMT2A (0.37) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL20626668 0.89 ADRB2 (0.43) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL17461514 0.89 THRB (0.40) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL24019227 0.89 KMT2A (0.41) KMT2AMAPTS1PR1AKR1C3AKR1C2
SCHEMBL20105079 0.89 KMT2A (0.43) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL22173898 0.89 ELANE (0.39) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL18541169 0.88 KMT2A (0.35) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL17719436 0.88 THRB (0.39) ALOX15KMT2AMAPTNPC1RAB9A
SCHEMBL16803383 0.88 THRB (0.39) ALOX15KMT2AMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2977428-B1 POLYMERIZABLE COMPOUND-CONTAINING LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT USING SAME DAINIPPON INK & CHEMICALS (JP) 2018-05-02 EP disclosed