Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | TACR1 | P25103 | 7/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11141618 | 1.00 | SLC6A2 (0.61) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| Hydrochloric Acid SCHEMBL15922321 | 0.98 | SLC6A2 (0.59) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| Hydrochloric Acid SCHEMBL15921749 | 0.98 | SLC6A2 (0.59) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| Hydrochloric Acid SCHEMBL15921747 | 0.98 | SLC6A2 (0.59) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| SCHEMBL27367888 | 0.82 | CHRNA7 (0.41) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| SCHEMBL1333875 | 0.81 | SLC6A2 (0.65) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| SCHEMBL24005933 | 0.77 | SLC6A2 (0.44) | SLC6A2ADRA1AHTR2BSLC6A3CHRNA7 | |
| Phenmetrazine SCHEMBL15159760 | 0.76 | SLC6A2 (1.00) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| Phenmetrazine SCHEMBL15154744 | 0.76 | SLC6A2 (1.00) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 | |
| Phenmetrazine SCHEMBL8094204 | 0.76 | SLC6A2 (1.00) | SLC6A2ADRA1AHTR2BSLC6A3TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |