Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 14/20 | 0.47 |
| ▸ | PRKACA | P17612 | 8/20 | 0.47 |
| ▸ | GSK3B | P49841 | 8/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.47 |
| ▸ | CDK2 | P24941 | 8/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 6/20 | 0.47 |
| ▸ | GSK3A | P49840 | 6/20 | 0.47 |
| ▸ | JAK3 | P52333 | 6/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.47 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.47 |
| ▸ | PRKCG | P05129 | 5/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.47 |
| ▸ | MARK3 | P27448 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011596 | 0.85 | MET (0.44) | PRKACAROCK2CDK2MAP4K4RPS6KA3 | |
| SCHEMBL2013526 | 0.83 | MET (0.44) | ROCK2CDK2MAP4K4RPS6KA3DAPK3 | |
| SCHEMBL2009613 | 0.82 | MET (0.55) | RPS6KA3JAK2MAPK1PDPK1MET | |
| SCHEMBL13685513 | 0.81 | MET (0.54) | CDC7PRKACAGSK3BROCK2CDK2 | |
| SCHEMBL13685509 | 0.78 | MET (0.44) | ROCK2RPS6KA3JAK3JAK2PDPK1 | |
| SCHEMBL1414765 | 0.77 | MET (0.66) | RPS6KA3JAK2MAPK1PDPK1MET | |
| SCHEMBL9906859 | 0.76 | MET (0.41) | ROCK2CDK2MAP4K4RPS6KA3DAPK3 | |
| SCHEMBL2014848 | 0.75 | MET (0.44) | RPS6KA3MAPK1METKDM4EALDH1A1 | |
| SCHEMBL4437474 | 0.75 | MET (0.58) | GSK3BRPS6KA3GSK3ACDK5DYRK1A | |
| SCHEMBL13685512 | 0.74 | ALDH1A1 (0.38) | KDM4EALDH1A1MAPTHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121608-B1 | DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | BAYER IP GMBH (DE) | 2012-11-14 | — | — | EP | claimed |
| WO-2011067189-A2 | CMET INHIBITORS FOR TREATING ENDOMETRIOSIS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-09 | — | — | WO | claimed |
| EP-2121608-A1 | DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma AG (DE) | 2009-11-25 | — | — | EP | claimed |
| US-20080176833-A1 | DIHYDROPYRIDINE DERIVATIVES AS USEFUL AS PROTEIN KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-07-24 | — | — | US | claimed |
| WO-2008071451-A1 | DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | claimed |
| EP-2121608-B1 | DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | BAYER IP GMBH (DE) | 2012-11-14 | — | — | EP | disclosed |
| US-8198456-B2 | e.g. 1,4-dihydro-4-(1H-indazol-5-yl)-2,6-dimethyl-3,5-pyridinedicarbonitrile; c-Met tyrosine kinase inhibitor; antitumor agent; lung, liver, gastric and breast solid tumors; pancreatic cancer, glioma, and hepatocellular carcinoma | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-06-12 | — | — | US | disclosed |
| WO-2011067189-A2 | CMET INHIBITORS FOR TREATING ENDOMETRIOSIS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-09 | — | — | WO | disclosed |
| EP-2121608-A1 | DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | Bayer Schering Pharma AG (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-20080176833-A1 | DIHYDROPYRIDINE DERIVATIVES AS USEFUL AS PROTEIN KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
| WO-2008071451-A1 | DIHYDROPYRIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176833-A1 | DIHYDROPYRIDINE DERIVATIVES AS USEFUL AS PROTEIN KINASE INHIBITORS | MET, DMPK, RET | CDC7 230/4885PRKACA 14/4885GSK3B 1493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.