SCHEMBL20106757

SCHEMBL20106757

CC(C)(C)OC(=O)N1CCC2(CC1)CC(N(C(=O)C(F)(F)F)C1CC1)C2

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 18/20 0.44
NAMPT P43490 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20106740 0.89 GPR119 (0.40) GPR119
SCHEMBL15507268 0.87 GPR119 (0.55) GPR119
SCHEMBL21088654 0.83 GPR119 (0.44) GPR119NAMPT
SCHEMBL21089246 0.80 CACNA1H (0.33) GPR119
SCHEMBL17410921 0.80 GPR119 (0.46) GPR119NAMPT
SCHEMBL16969327 0.77 USP2 (0.47) GPR119NAMPT
SCHEMBL21388117 0.76 GPR119 (0.39) GPR119
SCHEMBL1474868 0.75 USP2 (0.49) GPR119NAMPT
SCHEMBL22305158 0.75 USP2 (0.49) GPR119NAMPT
SCHEMBL18357800 0.75 GPR119 (0.44) GPR119NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3532459-B1 LSD1 INHIBITORS AND MEDICAL USES THEREOF CONSTELLATION PHARMACEUTICALS INC (US) 2023-08-02 EP disclosed
EP-3286172-B1 LSD1 INHIBITORS AND USES THEREOF CONSTELLATION PHARMACEUTICALS INC (US) 2019-06-12 EP disclosed
WO-2018081343-A1 LSD1 INHIBITORS AND MEDICAL USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. (US) 2018-05-03 WO disclosed