SCHEMBL20106858

SCHEMBL20106858

O=C(N(C1CC1)C1CC2(CNC2)C1)C(F)(F)F

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
P2RY14 Q15391 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20106743 0.84
SCHEMBL15507272 0.77 SLC6A4 (0.39)
Hydrochloric Acid SCHEMBL22797965 0.75 SLC6A4 (0.38)
SCHEMBL25924019 0.74
SCHEMBL19609175 0.73 MAOA (0.36) P2RY14
SCHEMBL20106862 0.73
SCHEMBL20106745 0.73 ITGB3 (0.30)
Hydrochloric Acid SCHEMBL22465821 0.72 MAOA (0.36) P2RY14
SCHEMBL21088402 0.72
SCHEMBL21088890 0.72 NR1I2 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3532459-B1 LSD1 INHIBITORS AND MEDICAL USES THEREOF CONSTELLATION PHARMACEUTICALS INC (US) 2023-08-02 EP disclosed
EP-3286172-B1 LSD1 INHIBITORS AND USES THEREOF CONSTELLATION PHARMACEUTICALS INC (US) 2019-06-12 EP disclosed
WO-2018081343-A1 LSD1 INHIBITORS AND MEDICAL USES THEREOF CONSTELLATION PHARMACEUTICALS, INC. (US) 2018-05-03 WO disclosed