⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6397097 | 0.79 | — | — | |
| SCHEMBL37725 | 0.72 | CYP19A1 (0.33) | — | |
| SCHEMBL577648 | 0.72 | CYP19A1 (0.33) | — | |
| SCHEMBL28335030 | 0.69 | ACHE (0.35) | — | |
| SCHEMBL22749545 | 0.68 | CYP19A1 (0.32) | — | |
| SCHEMBL24786222 | 0.65 | CYP2D6 (0.35) | — | |
| SCHEMBL4234812 | 0.65 | GRIN1 (0.33) | — | |
| SCHEMBL790377 | 0.64 | DRD2 (0.36) | — | |
| SCHEMBL22579802 | 0.61 | TDP1 (0.42) | — | |
| SCHEMBL6397093 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964632-B2 | Methods of treatment using a prodrug of an excitatory amino acid | ELI LILLY AND COMPANY (US) | 2011-06-21 | — | — | US | disclosed |
| US-20100113579-A1 | PRODRUGS OF EXCITATORY AMINO ACIDS | ELI LILLY AND COMPANY (US) | 2010-05-06 | — | — | US | disclosed |
| US-7671082-B2 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY (US) | 2010-03-02 | — | — | US | disclosed |
| US-20080182889-A1 | PRODRUGS OF EXCITATORY AMINO ACIDS | MOHER ERIC DAVID | 2008-07-31 | — | — | US | disclosed |