Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20107976 | 0.88 | KDM4E (0.38) | L3MBTL1KDM4EALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL5604030 | 0.84 | L3MBTL1 (0.41) | L3MBTL1KDM4EALDH1A1TAS2R14SMN1; SMN2 | |
| SCHEMBL31535215 | 0.77 | THRA (0.50) | L3MBTL1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL30316357 | 0.77 | HSD17B10 (0.50) | KDM4EALDH1A1HSD17B10TSHRHPGD | |
| SCHEMBL7559576 | 0.76 | SMN1; SMN2 (0.40) | L3MBTL1KDM4EALDH1A1TAS2R14SMN1; SMN2 | |
| SCHEMBL29816669 | 0.75 | DHODH (0.38) | KDM4EALDH1A1TAS2R14HSD17B10TSHR | |
| SCHEMBL20108093 | 0.75 | DHODH (0.38) | KDM4EALDH1A1TAS2R14HSD17B10TSHR | |
| SCHEMBL21853468 | 0.75 | DHODH (0.38) | KDM4EALDH1A1TAS2R14HSD17B10TSHR | |
| SCHEMBL7554664 | 0.74 | SCN9A (0.35) | L3MBTL1KDM4EALDH1A1TAS2R14MEN1 | |
| SCHEMBL6600427 | 0.73 | FABP3 (0.47) | L3MBTL1KDM4EALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532468-B1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AG (DE) | 2022-03-23 | — | — | EP | disclosed |
| WO-2018077923-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |