SCHEMBL20108197

SCHEMBL20108197

N#Cc1ccc(Br)cc1OCC(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 2/20 0.44
MAOB P27338 3/20 0.41
MAOA P21397 2/20 0.41
KDM4E B2RXH2 2/20 0.40
MEN1 O00255 1/20 0.40
USP2 O75604 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
MAPT P10636 1/20 0.40
THRB P10828 1/20 0.40
G6PD P11413 1/20 0.40
ALOX15 P16050 1/20 0.40
CASP1 P29466 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HRH4 Q9H3N8 1/20 0.39
AR P10275 6/20 0.37
S1PR1 P21453 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12128120 0.90 AAK1 (0.49) AAK1MAOBMAOAKDM4EMEN1
SCHEMBL3746625 0.82 FFAR1 (0.49) AAK1KDM4EMEN1USP2ALDH1A1
SCHEMBL31195886 0.81 MAOB (0.44) AAK1MAOBMAOAARNOS3
SCHEMBL24697702 0.81 AAK1 (0.47) AAK1MAOBMAOAAR
SCHEMBL8149842 0.81 AR (0.38) AAK1MAOBMAOAKDM4EMEN1
SCHEMBL18122079 0.81 AR (0.52) AAK1KDM4EMEN1USP2ALDH1A1
SCHEMBL16422592 0.81 AR (0.47) KDM4EMEN1USP2ALDH1A1HSP90AA1
SCHEMBL20107968 0.79 AR (0.39) AAK1KDM4EMEN1USP2ALDH1A1
SCHEMBL8522538 0.79 ALDH1A1 (0.47) KDM4EMEN1USP2ALDH1A1HSP90AA1
SCHEMBL16071292 0.78 AAK1 (0.53) AAK1MAOBMAOAAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3532468-B1 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH BAYER AG (DE) 2022-03-23 EP disclosed
WO-2018077923-A1 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH BAYER AKTIENGESELLSCHAFT (DE) 2018-05-03 WO disclosed
WO-2018077944-A2 4,5-ANNULATED 1,2,4-TRIAZOLONES BAYER AKTIENGESELLSCHAFT (DE) 2018-05-03 WO disclosed