Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 15/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20108197 | 0.81 | AAK1 (0.44) | AAK1MAOAMAOBAR | |
| SCHEMBL29363898 | 0.79 | EGFR (0.44) | AAK1MAOAMAOBAR | |
| SCHEMBL746850 | 0.79 | EGFR (0.44) | AAK1MAOAMAOBAR | |
| SCHEMBL1331302 | 0.78 | AAK1 (0.55) | AAK1MAOAMAOBAR | |
| SCHEMBL17143604 | 0.78 | AAK1 (0.64) | AAK1 | |
| SCHEMBL17143607 | 0.78 | AAK1 (0.64) | AAK1 | |
| SCHEMBL27784294 | 0.78 | HTR1A (0.50) | AAK1MAOAAR | |
| SCHEMBL14820128 | 0.76 | MAOB (0.42) | AAK1MAOAMAOBAR | |
| SCHEMBL16071292 | 0.76 | AAK1 (0.53) | AAK1MAOAMAOBAR | |
| SCHEMBL12144473 | 0.76 | AAK1 (0.56) | AAK1MAOAMAOBAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-11 | — | — | US | disclosed |
| WO-2022246179-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. (US) | 2022-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | AXL, BTK, MERTK | AAK1 313/4885MAOA 3763/4885MAOB 3193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.