Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | USP8 | P40818 | 1/20 | 0.30 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17234682 | 0.73 | DYRK1A (0.38) | DYRK1AKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL30370935 | 0.73 | DYRK1A (0.38) | DYRK1AKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL31314315 | 0.69 | TDP1 (0.53) | DYRK1AMAPK14KDM4EALDH1A1GAA | |
| SCHEMBL4744938 | 0.69 | TDP1 (0.53) | DYRK1AMAPK14KDM4EALDH1A1GAA | |
| SCHEMBL6917872 | 0.68 | ALDH1A1 (0.40) | DYRK1AKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL30577635 | 0.67 | CYP2A6 (0.48) | CYP2A6DYRK1APSMB8PSMB5 | |
| SCHEMBL14629332 | 0.67 | CYP2A6 (0.48) | CYP2A6DYRK1APSMB8PSMB5 | |
| SCHEMBL30896559 | 0.66 | DYRK1A (0.38) | DYRK1AKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL22792965 | 0.64 | DYRK1A (0.37) | DYRK1AMAPT | |
| SCHEMBL8122154 | 0.64 | CYP2A6 (0.46) | CYP2A6KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |