Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25633195 | 0.85 | CHRNB2 (0.46) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL16015437 | 0.85 | CHRNB2 (0.46) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL24456539 | 0.83 | DPP8 (0.47) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL12521658 | 0.83 | DPP8 (0.47) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL24820003 | 0.81 | ALDH1A1 (0.56) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL12197568 | 0.81 | NAMPT (0.47) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL24456541 | 0.81 | DPP8 (0.46) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL11892685 | 0.81 | CHRNB2 (0.49) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL25477547 | 0.80 | DPP8 (0.42) | DPP8DPP7TACR3MEN1POLB | |
| SCHEMBL24456619 | 0.80 | DPP8 (0.42) | DPP8DPP7TACR3MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534152-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-02 | — | — | EP | disclosed |