Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | GHSR | Q92847 | 3/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1485223 | 1.00 | HTR6 (0.55) | HTR6POLBHTR2AGHSRCHRNB4 | |
| SCHEMBL478235 | 0.95 | POLB (0.60) | HTR6POLBHTR2AGHSR | |
| SCHEMBL23459399 | 0.93 | POLB (0.58) | HTR6POLBHTR2AGHSR | |
| SCHEMBL22455764 | 0.83 | HTR6 (0.55) | HTR6POLBHTR2ACHRNB4CHRNA3 | |
| SCHEMBL31189119 | 0.81 | POLB (0.50) | HTR6POLBHTR2ACHRNB4CHRNA3 | |
| SCHEMBL6800803 | 0.80 | HTR6 (0.46) | HTR6POLBHTR2A | |
| SCHEMBL18019790 | 0.79 | HTR6 (0.55) | HTR6POLBHTR2AGHSR | |
| SCHEMBL6796105 | 0.79 | HTR6 (0.55) | HTR6POLBHTR2AGHSR | |
| SCHEMBL469052 | 0.79 | HTR2A (0.61) | HTR6POLBHTR2A | |
| SCHEMBL18019793 | 0.79 | HTR6 (0.55) | HTR6POLBHTR2AGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118721-A1 | PYRIMIDINE DERIVATIVES | MTHFD1, TYMS, DPYD | HTR6 3568/4885POLB 546/4885HTR2A 3436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.