Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.36 |
| ▸ | LPL | P06858 | 7/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 3/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17903572 | 0.88 | PDGFRB (0.36) | LIPGLPLHIF1AIRAK4FFAR1 | |
| SCHEMBL31207697 | 0.88 | PDGFRB (0.36) | LIPGLPLHIF1AIRAK4FFAR1 | |
| SCHEMBL20110055 | 0.88 | ROCK1 (0.38) | LIPGLPLHIF1AIRAK4PRMT5 | |
| SCHEMBL20110067 | 0.86 | CSF1R (0.40) | LIPGLPLHIF1AIRAK4PRMT5 | |
| SCHEMBL19652465 | 0.84 | LIPG (0.43) | LIPGLPLHIF1AFFAR1 | |
| SCHEMBL17903421 | 0.84 | LIPG (0.43) | LIPGLPLHIF1AFFAR1 | |
| SCHEMBL19652467 | 0.84 | LIPG (0.43) | LIPGLPLHIF1AFFAR1 | |
| SCHEMBL20110062 | 0.78 | CNR1 (0.32) | LMNAMAPT | |
| SCHEMBL17903420 | 0.76 | LPL (0.49) | LIPGLPLCASRFFAR1 | |
| SCHEMBL17903571 | 0.76 | ROCK1 (0.38) | LIPGLPLHIF1AFFAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118766-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118766-A1 | BTK INHIBITORS | BTK, SYK, LYN | LIPG 1114/4885LPL 2228/4885HIF1A 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.