SCHEMBL2011023

SCHEMBL2011023

COc1ccc(Cl)cc1NC(=O)CC(=O)Nc1cc(Cl)ccc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 1.00
KMT2A Q03164 4/20 1.00
ALDH1A1 P00352 7/20 0.85
SMN1; SMN2 Q16637 2/20 0.74
POLB P06746 3/20 0.70
LMNA P02545 1/20 0.67
NPSR1 Q6W5P4 2/20 0.65
CYP1A2 P05177 1/20 0.65
CYP2C19 P33261 1/20 0.65
NPC1 O15118 1/20 0.62
KDM4E B2RXH2 1/20 0.62
MAPT P10636 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8824794 0.92 ALDH1A1 (1.00) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL9468747 0.90 KMT2A (0.82) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL14192656 0.90 KMT2A (0.82) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL12300221 0.90 MEN1 (0.82) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL7931375 0.89 KMT2A (0.80) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL2374142 0.89 MEN1 (0.80) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL13329336 0.89 KMT2A (0.80) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL10604241 0.89 MEN1 (0.80) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL30662094 0.88 MEN1 (0.78) MEN1KMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL22693560 0.86 KMT2A (0.76) MEN1KMT2AALDH1A1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10398680-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-09-03 US disclosed
US-10398749-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-09-03 US disclosed
US-20190240195-A1 METHODS OF TREATING MUSCULAR DYSTROPHY Board of Regents of the Nevada System of Higher Education, on behalf of the Univ of Nevada, Reno (US) 2019-08-08 US disclosed
US-10272069-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-04-30 US disclosed
US-10206903-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-02-19 US disclosed
US-10028992-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2018-07-24 US disclosed
US-10028992-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2018-07-24 US disclosed
EP-2892525-B1 METHODS OF TREATING MUSCULAR DYSTROPHY UNIV NEVADA RENO (US) 2018-06-13 EP disclosed
US-9980943-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEMS OF HIGHER EDUCATION ON BEHALF OF THE NEVADA, RENO (US) 2018-05-29 US disclosed
US-9980943-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEMS OF HIGHER EDUCATION ON BEHALF OF THE NEVADA, RENO (US) 2018-05-29 US disclosed
US-20150290276-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY 2015-10-15 US disclosed
US-20150290276-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY 2015-10-15 US disclosed
WO-2014040077-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSISITY OF NEVADA, RENO (US) 2014-03-13 WO disclosed
US-20140072536-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA (US) 2014-03-13 US disclosed
US-20140072536-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA (US) 2014-03-13 US disclosed
US-7964625-B2 Antibiotics comprising bis(1-aryl-5-tetrazoly1)methane derivatives NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2011-06-21 US disclosed
EP-1937257-B1 NOVEL ANTIBIOTICS COMPRISING BIS(1-ARYL-5-TETRAZ0LYL)METHANE DERIVATIVES TNO (NL) 2010-12-08 EP disclosed
US-20080280964-A1 Novel Antibiotics Comprising Bis(1-Aryl-5-Tetrazolyl)Methane Derivatives NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2008-11-13 US disclosed
EP-1937257-A1 NOVEL ANTIBIOTICS COMPRISING BIS(1-ARYL-5-TETRAZ0LYL)METHANE DERIVATIVES Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO (NL) 2008-07-02 EP disclosed
WO-2007037685-A1 NOVEL ANTIBIOTICS COMPRISING BIS(1-ARYL-5-TETRAZ0LYL)METHANE DERIVATIVES NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2007-04-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150290276-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-10272069-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-10028992-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-10398680-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-10398749-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-20190240195-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-10206903-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-20140072536-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 MEN1 4859/4885KMT2A 3360/4885ALDH1A1 342/4885
US-20080280964-A1 Novel Antibiotics Comprising Bis(1-Aryl-5-Tetrazolyl)Methane Derivatives LAS1L, AAAS, RPS5 MEN1 1009/4885KMT2A 2575/4885ALDH1A1 3743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.