Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | GRK2 | P25098 | 1/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011023 | 0.89 | MEN1 (1.00) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL12300221 | 0.86 | MEN1 (0.82) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL9468747 | 0.86 | KMT2A (0.82) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL14192656 | 0.86 | KMT2A (0.82) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8824794 | 0.85 | ALDH1A1 (1.00) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL13329336 | 0.85 | KMT2A (0.80) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7931375 | 0.85 | KMT2A (0.80) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL10604241 | 0.85 | MEN1 (0.80) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL30662094 | 0.84 | MEN1 (0.78) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL24499463 | 0.83 | KMT2A (0.55) | MEN1KMT2AALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552914-B1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2015-11-11 | — | — | EP | disclosed |
| US-9029387-B2 | Benzonaphthyridinamines as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| WO-2014192865-A1 | PHENYLPIPERAZINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2014-12-04 | — | — | WO | disclosed |
| EP-2552914-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2013-02-06 | — | — | EP | disclosed |
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-01-10 | — | — | US | disclosed |
| WO-2011116867-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2011-09-29 | — | — | WO | disclosed |
| US-20110230471-A1 | BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-09-22 | — | — | US | disclosed |
| US-20110230471-A1 | BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-09-22 | — | — | US | disclosed |
| WO-2010060532-A1 | BENZONAPHTYRIDINE COMPOUNDS USED AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | ENPP2, LYPLAL1, LYPLA1 | MEN1 1075/4885KMT2A 572/4885ALDH1A1 3057/4885 |
| US-20110230471-A1 | BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN | ENPP2, TPX2, TPD52L2 | MEN1 226/4885KMT2A 1069/4885ALDH1A1 4584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.