Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6635259 | 0.84 | HDAC3 (0.59) | HDAC3MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL6636483 | 0.81 | MAPT (0.52) | HDAC3MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL6636541 | 0.80 | CASP2 (0.53) | HDAC3MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL20111783 | 0.79 | MEN1 (0.39) | HDAC3MAPTKMT2AMEN1HDAC1 | |
| SCHEMBL5718051 | 0.79 | HSP90AA1 (0.47) | HDAC3MAPTKMT2AMEN1HDAC1 | |
| SCHEMBL15694051 | 0.76 | KMT2A (0.65) | MAPTKMT2AMEN1NPSR1FAAH | |
| SCHEMBL4662735 | 0.76 | HDAC3 (0.61) | HDAC3MAPTKMT2AMEN1HDAC1 | |
| SCHEMBL2416986 | 0.76 | HDAC3 (0.61) | HDAC3MAPTKMT2AMEN1HDAC1 | |
| SCHEMBL6636306 | 0.76 | HSP90AA1 (0.57) | HDAC3MAPTKMT2AMEN1HDAC1 | |
| SCHEMBL6641767 | 0.76 | HSP90AA1 (0.57) | HDAC3MAPTKMT2AMEN1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081530-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-05-03 | — | — | WO | disclosed |