Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 14/20 | 0.44 |
| ▸ | ELOC | Q15369 | 13/20 | 0.44 |
| ▸ | ELOB | Q15370 | 13/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22790711 | 1.00 | VHL (0.44) | VHLELOCELOBATMPIN1 | |
| SCHEMBL22777163 | 0.88 | ATM (0.58) | VHLELOCELOBATMDPP4 | |
| SCHEMBL22777165 | 0.88 | ATM (0.58) | VHLELOCELOBATMDPP4 | |
| SCHEMBL24262637 | 0.87 | DPP4 (0.39) | VHLELOCELOBATMDPP4 | |
| SCHEMBL24262437 | 0.86 | DPP4 (0.42) | VHLELOCELOBATMDPP4 | |
| SCHEMBL21350354 | 0.86 | DPP4 (0.42) | VHLELOCELOBATMDPP4 | |
| SCHEMBL31605674 | 0.86 | VHL (0.40) | VHLELOCELOBATMDPP4 | |
| SCHEMBL28577731 | 0.85 | MMP2 (0.47) | VHLELOCELOBATM | |
| SCHEMBL24103548 | 0.85 | VHL (0.40) | VHLELOCELOBDPP4DPP8 | |
| SCHEMBL24592324 | 0.85 | ELANE (0.44) | VHLELOCELOBDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081530-A1 | COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-05-03 | — | — | WO | disclosed |