SCHEMBL2011159

SCHEMBL2011159

COC(=O)COc1ccc(C(=O)CN2Cc3cc(C(=N)SC)ccc3C2=O)cc1

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 5/20 0.44
ITGA2B P08514 5/20 0.44
AOC3 Q16853 8/20 0.41
MAPT P10636 2/20 0.40
NPC1 O15118 2/20 0.40
KDM4E B2RXH2 1/20 0.40
RAB9A P51151 1/20 0.40
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2008897 0.91 ITGB3 (0.43) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2009664 0.90 ITGB3 (0.42) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2009990 0.89 ITGB3 (0.55) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2009998 0.88 ITGB3 (0.41) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2008668 0.88 ITGB3 (0.45) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2010110 0.87 ITGB3 (0.48) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2013975 0.86 ITGB3 (0.42) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2009891 0.85 ITGB3 (0.38) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2009838 0.85 ITGB3 (0.46) ITGB3ITGA2BAOC3MAPTNPC1
SCHEMBL2008928 0.83 AOC3 (0.42) ITGB3ITGA2BAOC3MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964628-B2 Fibrinogen receptor antagonists and their use PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-06-21 US disclosed
US-20100256161-A1 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE PIRAMAL LIFE SCIENCES LIMITED (IN) 2010-10-07 US disclosed
US-7759387-B2 Fibrinogen receptor antagonists and their use PIRAMAL LIFE SCIENCES LIMITED (IN) 2010-07-20 US disclosed
US-20070021489-A1 Fibrinogen receptor antagonists and their use NICHOLAS PIRAMAL INDIA LIMITED (IN) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256161-A1 FIBRINOGEN RECEPTOR ANTAGONISTS AND THEIR USE FGB, F13B, F2 ITGB3 169/4885ITGA2B 63/4885AOC3 3283/4885
US-20070021489-A1 Fibrinogen receptor antagonists and their use FGB, F13B, F2 ITGB3 169/4885ITGA2B 63/4885AOC3 3283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.