Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20111636 | 0.89 | MCOLN3 (0.41) | MCOLN3MEN1KMT2ATDP1LMNA | |
| SCHEMBL20111632 | 0.83 | JAK2 (0.32) | MEN1KMT2ALMNAPIK3CAHRH3 | |
| SCHEMBL20111629 | 0.78 | PIK3CA (0.32) | PIK3CAJAK2JAK1 | |
| SCHEMBL24261284 | 0.76 | PIK3CA (0.35) | PIK3CAJAK2JAK1TSHR | |
| SCHEMBL20711788 | 0.76 | PIK3CA (0.35) | PIK3CAJAK2JAK1 | |
| SCHEMBL12206044 | 0.76 | PIK3CA (0.35) | PIK3CAJAK2JAK1TSHR | |
| SCHEMBL8263008 | 0.75 | MEN1 (0.47) | MCOLN3MEN1KMT2ATDP1LMNA | |
| SCHEMBL20609751 | 0.74 | PIK3CA (0.37) | PIK3CAJAK2JAK1 | |
| SCHEMBL22198736 | 0.73 | JAK2 (0.38) | PIK3CAJAK2JAK1 | |
| SCHEMBL738020 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078360-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2018-05-03 | — | — | WO | disclosed |