Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20111913 | 0.87 | POLB (0.34) | LMNAGAAPOLBAPOBEC3AAPOBEC3G | |
| SCHEMBL20111628 | 0.83 | MCOLN3 (0.40) | JAK2JAK1PIK3CALMNAPOLB | |
| SCHEMBL20111634 | 0.78 | SMYD3 (0.31) | JAK2JAK1PIK3CA | |
| SCHEMBL20111953 | 0.77 | SMYD3 (0.40) | LMNAPOLBAPOBEC3AAPOBEC3GMEN1 | |
| SCHEMBL24261284 | 0.76 | PIK3CA (0.35) | JAK2JAK1PIK3CA | |
| SCHEMBL20711788 | 0.76 | PIK3CA (0.35) | JAK2JAK1PIK3CA | |
| SCHEMBL12206044 | 0.76 | PIK3CA (0.35) | JAK2JAK1PIK3CA | |
| SCHEMBL10192196 | 0.75 | POLB (0.41) | LMNAPOLBAPOBEC3AAPOBEC3GMEN1 | |
| SCHEMBL20609751 | 0.74 | PIK3CA (0.37) | JAK2JAK1PIK3CA | |
| SCHEMBL14883722 | 0.74 | LMNA (0.44) | LMNAGAAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078360-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2018-05-03 | — | — | WO | disclosed |