Sugi Predict

Sugi Predict / Compounds / SCHEMBL20112728

SCHEMBL20112728

SCHEMBL20112728

Clc1nccc2c1CCCN2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIA1 P42261 1/20 0.40
▸ GRIA2 P42262 1/20 0.40
▸ GRIA3 P42263 1/20 0.40
▸ GRIA4 P48058 1/20 0.40
▸ NOTUM Q6P988 1/20 0.40
▸ BCHE P06276 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ MAPT P10636 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ ALOX15 P16050 1/20 0.36
▸ ALOX12 P18054 1/20 0.36
▸ MPI P34949 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ CA12 O43570 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30047871 1.00 GRIA1 (0.40) GRIA1GRIA2GRIA3GRIA4NOTUM
SCHEMBL6703378 0.88 NOTUM (0.52) NOTUMBCHEHTT
Hydrochloric Acid SCHEMBL18168201 0.86 NOTUM (0.50) NOTUMBCHEHTT
SCHEMBL19153130 0.81 UHRF1 (0.41) GRIA1GRIA2GRIA3GRIA4NOTUM
SCHEMBL20571119 0.74 GRIA1 (0.39) GRIA1GRIA2GRIA3GRIA4BCHE
SCHEMBL4929162 0.74 GRIA1 (0.55) GRIA1GRIA2GRIA3GRIA4NOTUM
SCHEMBL1330038 0.73 UHRF1 (0.41) GRIA1GRIA2GRIA3GRIA4NOTUM
SCHEMBL20571507 0.73 GRIA1 (0.37) GRIA1GRIA2GRIA3GRIA4NOTUM
SCHEMBL20571884 0.73 GRIA1 (0.37) GRIA1GRIA2GRIA3GRIA4BCHE
SCHEMBL20571511 0.73 GRIA1 (0.37) GRIA1GRIA2GRIA3GRIA4NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3630770-B1 PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS RELAY THERAPEUTICS INC (US) 2024-08-28 — — EP disclosed
US-20240199596-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-06-20 — — US disclosed
US-11999733-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-06-04 — — US disclosed
US-11976072-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-05-07 — — US disclosed
EP-4359413-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2024-05-01 — — EP disclosed
EP-4359411-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2024-05-01 — — EP disclosed
US-11932634-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-03-19 — — US disclosed
US-11926628-B2 Diacylglyercol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-03-12 — — US disclosed
CN-117480155-A Diacylglycerol kinase modulating compounds 吉利德科学公司 2024-01-30 — — CN disclosed
CN-117396478-A Diacylglycerol kinase modulating compounds 吉利德科学公司 2024-01-12 — — CN disclosed
WO-2022271659-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 — — WO disclosed
WO-2022271677-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 — — WO disclosed
WO-2022271650-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 — — WO disclosed
US-20200172546-A1 PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS RELAY THERAPEUTICS, INC. 2020-06-04 — — US disclosed
US-20200172546-A1 PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS RELAY THERAPEUTICS, INC. 2020-06-04 — — US disclosed
EP-3630770-A1 PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS Relay Therapeutics, Inc. (US) 2020-04-08 — — EP disclosed
US-20200062760-A1 SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. 2020-02-27 — — US disclosed
US-20200062760-A1 SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. 2020-02-27 — — US disclosed
WO-2018218133-A1 PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS RELAY THERAPEUTICS, INC. (US) 2018-11-29 — — WO disclosed
WO-2018081091-A1 PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS RELAY THERAPEUTICS, INC. (US) 2018-05-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200062760-A1 SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF PTPRCAP, PTPRJ, PTPRC GRIA1 877/4885GRIA2 818/4885GRIA3 849/4885
US-20200172546-A1 PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS PTPRJ, PTPN2, PTPN5 GRIA1 1262/4885GRIA2 1006/4885GRIA3 1034/4885
US-11932634-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK GRIA1 2563/4885GRIA2 2759/4885GRIA3 2565/4885
US-11976072-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK GRIA1 2563/4885GRIA2 2759/4885GRIA3 2565/4885
US-20240199596-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK GRIA1 2563/4885GRIA2 2759/4885GRIA3 2565/4885
US-11926628-B2 Diacylglyercol kinase modulating compounds DGKG, DGKB, DGKK GRIA1 2129/4885GRIA2 2347/4885GRIA3 2395/4885
US-11999733-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK GRIA1 2563/4885GRIA2 2759/4885GRIA3 2565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.