Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAPDH | P04406 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303014 | 0.93 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL21142059 | 0.91 | NPC1 (0.48) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL22071979 | 0.89 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL16133519 | 0.89 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL18522409 | 0.89 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL18486787 | 0.89 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL18699548 | 0.88 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL10023970 | 0.87 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL20172076 | 0.87 | RXFP1 (0.59) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL23366546 | 0.86 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3162875-B1 | POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS | MERCK PATENT GMBH (DE) | 2018-05-23 | — | — | EP | disclosed |
| US-20180119010-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | US | disclosed |