Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20085883 | 0.92 | TRPA1 (0.39) | TRPA1TGFBR1METPTGS2CSNK1E | |
| SCHEMBL20085855 | 0.87 | TRPA1 (0.41) | TRPA1ADORA2A | |
| SCHEMBL20085882 | 0.85 | TRPA1 (0.46) | TRPA1TGFBR1METPTGS2CSNK1E | |
| SCHEMBL20085884 | 0.83 | TRPA1 (0.38) | TRPA1TGFBR1PTGS2CSNK1EADORA3 | |
| SCHEMBL20085887 | 0.83 | TRPA1 (0.38) | TRPA1TGFBR1PTGS2PGR | |
| SCHEMBL20088875 | 0.82 | TRPA1 (0.50) | TRPA1ADORA2A | |
| SCHEMBL20085844 | 0.81 | ALDH1A1 (0.39) | TRPA1TGFBR1PTGS2 | |
| SCHEMBL20085852 | 0.81 | ALDH1A1 (0.41) | TRPA1PTGS2 | |
| SCHEMBL20085859 | 0.80 | TRPA1 (0.38) | TRPA1GRIA1ADORA2A | |
| SCHEMBL20085843 | 0.78 | ADORA2A (0.46) | TRPA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532476-B1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-19 | — | — | EP | claimed |
| EP-3532476-B1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-19 | — | — | EP | disclosed |
| WO-2018080916-A1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |