Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20112873 | 0.88 | ADORA2A (0.35) | ADORA2ATGFBR1 | |
| SCHEMBL20088953 | 0.87 | TRPA1 (0.45) | TRPA1ADORA2A | |
| SCHEMBL20088876 | 0.84 | TRPA1 (0.43) | TRPA1ADORA2A | |
| SCHEMBL20088889 | 0.82 | TRPA1 (0.41) | TRPA1ADORA2A | |
| SCHEMBL20088985 | 0.82 | TRPA1 (0.50) | TRPA1ADORA2ATGFBR1 | |
| SCHEMBL20088890 | 0.81 | ADORA2A (0.37) | TRPA1ADORA2A | |
| SCHEMBL20085909 | 0.80 | TRPA1 (0.41) | TRPA1ADORA2ATGFBR1 | |
| SCHEMBL20089018 | 0.80 | TRPA1 (0.43) | TRPA1ADORA2A | |
| SCHEMBL20085899 | 0.77 | TRPA1 (0.46) | TRPA1ADORA2A | |
| SCHEMBL20112917 | 0.74 | ADORA2A (0.35) | TRPA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532476-B1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-19 | — | — | EP | claimed |
| EP-3532476-B1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-19 | — | — | EP | disclosed |
| WO-2018080916-A1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |