Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | APP | P05067 | 8/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CASP1 | P29466 | 2/20 | 0.61 |
| ▸ | HBB | P68871 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALPG | P10696 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011431 | 1.00 | RELA (0.65) | RELAMAPTAPPMEN1KMT2A | |
| SCHEMBL1714446 | 0.88 | RELA (0.81) | RELAMAPTAPPMEN1KMT2A | |
| SCHEMBL3025040 | 0.88 | RELA (0.81) | RELAMAPTAPPMEN1KMT2A | |
| SCHEMBL7915381 | 0.88 | RELA (0.81) | RELAMAPTAPPMEN1KMT2A | |
| SCHEMBL1714449 | 0.88 | RELA (0.81) | RELAMAPTAPPMEN1KMT2A | |
| SCHEMBL13467434 | 0.88 | RELA (0.81) | RELAMAPTAPPMEN1KMT2A | |
| SCHEMBL29389358 | 0.85 | RELA (0.77) | RELAMAPTAPPMEN1KMT2A | |
| SCHEMBL59844 | 0.85 | ALDH1A1 (0.69) | MAPTAPPMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11139551 | 0.83 | HSD17B3 (0.83) | MAPTAPPMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11139554 | 0.83 | HSD17B3 (0.83) | MAPTAPPMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170315137-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-02 | — | — | US | disclosed |
| US-9551722-B2 | Amyloid binding agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150177262-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| EP-2509940-B1 | AMYLOID BINDING AGENTS | UNIV CALIFORNIA (US) | 2015-06-10 | — | — | EP | disclosed |
| US-8940918-B2 | Amyloid binding agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-01-27 | — | — | US | disclosed |
| US-20120302603-A1 | AMYLOID BINDING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-29 | — | — | US | disclosed |
| EP-2509940-A2 | AMYLOID BINDING AGENTS | The Regents of the University of California (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072257-A2 | AMYLOID BINDING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-16 | — | — | WO | disclosed |
| US-7423133-B2 | Fluorescent glycosides and methods for their use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2008-09-09 | — | — | US | disclosed |
| US-20040215012-A1 | FLUORESCENT GLYCOSIDES AND METHODS FOR THEIR USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2004-10-28 | — | — | US | disclosed |
| WO-2004019002-A2 | FLUORESCENT GLYCOSIDES AND METHODS FOR THEIR USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2004-03-04 | — | — | WO | disclosed |
| EP-0242170-A2 | Divinyl compounds and chromogenic recording-material prepared by use thereof | YAMADA CHEMICAL CO., LTD. (JP) | 1987-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302603-A1 | AMYLOID BINDING AGENTS | APP, APBA1, PSEN1 | RELA 3753/4885MAPT 6/4885APP 1/4885 |
| US-20170315137-A1 | AMYLOID BINDING AGENTS | APBA1, APP, PSEN1 | RELA 3664/4885MAPT 5/4885APP 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.