Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.53 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.53 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | XPO1 | O14980 | 1/20 | 0.51 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241709 | 0.87 | TSHR (0.75) | TSHRNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL5290594 | 0.85 | MEN1 (0.72) | TSHRLMNAALDH1A1MAPTRAB9A | |
| SCHEMBL8947277 | 0.77 | TRPV1 (0.50) | TSHRLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12377871 | 0.77 | TRPM8 (0.62) | TSHRLMNANPC1ALDH1A1MAPT | |
| SCHEMBL15647225 | 0.75 | KMT2A (0.66) | TSHRLMNANPC1ALDH1A1MAPT | |
| SCHEMBL512955 | 0.75 | LMNA (0.63) | TSHRLMNANPC1ALDH1A1MAPT | |
| SCHEMBL18383425 | 0.73 | LMNA (0.47) | TSHRLMNANPC1ALDH1A1MAPT | |
| SCHEMBL13631406 | 0.72 | TSHR (0.50) | TSHRLMNANPC1ALDH1A1MAPT | |
| SCHEMBL24763566 | 0.72 | TP53 (0.64) | TP53 | |
| SCHEMBL14982246 | 0.71 | HTT (0.50) | TSHRLMNAALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616450-B1 | SULFONAMIDE COMPOUNDS | KANCERA AB (SE) | 2018-05-02 | — | — | EP | disclosed |