SCHEMBL20114559

SCHEMBL20114559

Cc1ccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(C#N)ccc2-c2nc(C)nc(C)n2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 3/20 0.42
MAPKAPK2 P49137 1/20 0.34
PDE9A O76083 1/20 0.32
PDE1C Q14123 1/20 0.32
PIK3CD O00329 1/20 0.32
PIK3CA P42336 1/20 0.32
FLT3 P36888 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
NPY5R Q15761 1/20 0.31
PDE10A Q9Y233 1/20 0.31
KDM4E B2RXH2 1/20 0.31
HPGD P15428 1/20 0.31
PPARG P37231 1/20 0.31
NCOA2 Q15596 1/20 0.31
NCOA1 Q15788 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
NCOA3 Q9Y6Q9 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA1 P30542 1/20 0.31
RORC P51449 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20114547 0.95 MAPKAPK2 (0.37) PTGER4MAPKAPK2PIK3CDPIK3CAFLT3
SCHEMBL20114689 0.94 PTGER4 (0.36) PTGER4MAPKAPK2PDE9APDE1CFLT3
SCHEMBL22268473 0.92 PTGER4 (0.40) PTGER4MAPKAPK2PDE9APDE1CPIK3CD
SCHEMBL20150390 0.92 PTGER4 (0.42) PTGER4MAPKAPK2PDE9APDE1CPIK3CD
SCHEMBL20114643 0.90 PTGER4 (0.39) PTGER4PIK3CDPIK3CAFLT3PDE10A
SCHEMBL20150367 0.89 PTGER4 (0.42) PTGER4L3MBTL1NPY5RKDM4EHPGD
SCHEMBL20114526 0.89 PTGER4 (0.37) PTGER4FLT3PDE10ALMNAMEN1
SCHEMBL20150346 0.88 CHEK1 (0.36) PTGER4MAPKAPK2PIK3CDPIK3CAFLT3
SCHEMBL20114686 0.88 ABCG2 (0.38) PTGER4MAPKAPK2PIK3CDPIK3CAKDM4E
SCHEMBL20114549 0.87 CLK4 (0.41) PTGER4LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices CYNORA GMBH (DE) 2019-09-24 US disclosed
EP-3315581-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-01-02 EP disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed
EP-3315581-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, EPCAM, F12 PTGER4 1809/4885MAPKAPK2 3348/4885PDE9A 4843/4885
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices OR10J3, EPCAM, F12 PTGER4 1809/4885MAPKAPK2 3348/4885PDE9A 4843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.