SCHEMBL20114689

SCHEMBL20114689

Cc1ccc(-c2ccc3c4ccccc4n(-c4cc(C#N)ccc4-c4nc(C)nc(C)n4)c3c2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 1/20 0.36
CHEK1 O14757 1/20 0.34
FLT3 P36888 8/20 0.33
PDE10A Q9Y233 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ATM Q13315 1/20 0.33
GRM2 Q14416 1/20 0.32
MAPKAPK2 P49137 1/20 0.32
PDE9A O76083 1/20 0.32
PDE1C Q14123 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
KDM4E B2RXH2 1/20 0.31
HPGD P15428 1/20 0.31
PPARG P37231 1/20 0.31
NCOA2 Q15596 1/20 0.31
NCOA1 Q15788 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20114643 0.96 PTGER4 (0.39) PTGER4CHEK1FLT3PDE10AMEN1
SCHEMBL20114526 0.95 PTGER4 (0.37) PTGER4CHEK1FLT3PDE10AMEN1
SCHEMBL20150346 0.95 CHEK1 (0.36) PTGER4CHEK1FLT3GRM2MAPKAPK2
SCHEMBL20114559 0.94 PTGER4 (0.42) PTGER4FLT3PDE10AMEN1KMT2A
SCHEMBL20114553 0.93 PTGER4 (0.36) PTGER4CHEK1FLT3PDE10AMEN1
SCHEMBL20150371 0.93 PTGER4 (0.38) PTGER4CHEK1PDE10AMEN1KMT2A
SCHEMBL20114546 0.92 PTGER4 (0.37) PTGER4FLT3PDE10AMEN1KMT2A
SCHEMBL20156124 0.92 CYP1A2 (0.38) PTGER4CHEK1MEN1KMT2ATP53
SCHEMBL20114554 0.92 PTGER4 (0.36) PTGER4CHEK1PDE10AMEN1KMT2A
SCHEMBL20150415 0.92 PTGER4 (0.36) PTGER4CHEK1FLT3PDE10AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices CYNORA GMBH (DE) 2019-09-24 US disclosed
EP-3315581-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-01-02 EP disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed
EP-3315581-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, EPCAM, F12 PTGER4 1809/4885CHEK1 2795/4885FLT3 2919/4885
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices OR10J3, EPCAM, F12 PTGER4 1809/4885CHEK1 2795/4885FLT3 2919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.