Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21695280 | 0.98 | MAP3K12 (0.60) | MAP3K12PIK3CA | |
| SCHEMBL20147765 | 0.97 | MAP3K12 (0.60) | MAP3K12PIK3CA | |
| SCHEMBL21695315 | 0.92 | MAP3K12 (0.62) | MAP3K12PIK3CA | |
| SCHEMBL21695290 | 0.91 | MAP3K12 (0.61) | MAP3K12PIK3CA | |
| SCHEMBL21695318 | 0.90 | MAP3K12 (0.61) | MAP3K12PIK3CA | |
| SCHEMBL21695313 | 0.90 | MAP3K12 (0.60) | MAP3K12PIK3CA | |
| SCHEMBL21695275 | 0.89 | MAP3K12 (0.64) | MAP3K12PIK3CA | |
| SCHEMBL21695268 | 0.88 | MAP3K12 (0.60) | MAP3K12PIK3CA | |
| SCHEMBL21695277 | 0.88 | MAP3K12 (0.61) | MAP3K12PIK3CA | |
| SCHEMBL21695279 | 0.88 | MAP3K12 (0.66) | MAP3K12PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180117044-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180117044-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | BCHE, SNCA, XDH | MAP3K12 2230/4885PIK3CA 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.