Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20115793 | 0.89 | SCN9A (0.37) | SCN9ACYP3A4SCN8ASCN5ASCN1A | |
| SCHEMBL20115736 | 0.80 | SCN9A (0.35) | SCN9ACYP3A4SCN8A | |
| SCHEMBL20115792 | 0.80 | SCN9A (0.36) | SCN9ACYP3A4SCN8A | |
| SCHEMBL20115568 | 0.80 | SCN9A (0.62) | SCN9ACYP3A4SCN8ASCN5A | |
| SCHEMBL30479337 | 0.80 | SCN9A (0.62) | SCN9ACYP3A4SCN8ASCN5A | |
| SCHEMBL20115586 | 0.72 | SCN9A (0.67) | SCN9ACYP3A4SCN5A | |
| SCHEMBL20115636 | 0.71 | SCN5A (0.65) | SCN9ACYP3A4SCN5A | |
| SCHEMBL31566501 | 0.70 | SCN9A (0.58) | SCN9ACYP3A4SCN8ASCN5ASCN1A | |
| SCHEMBL21707538 | 0.70 | SCN9A (0.56) | SCN9ACYP3A4SCN8ASCN5ASCN1A | |
| SCHEMBL25975292 | 0.70 | SCN1A (0.38) | SCN8ASCN5ALMNASMN1; SMN2SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081384-A1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-03 | — | — | WO | disclosed |