Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20115736 | 0.90 | SCN9A (0.35) | SCN9ACYP3A4SCN8A | |
| SCHEMBL30479334 | 0.81 | SCN9A (0.57) | SCN9ACYP3A4SCN8A | |
| SCHEMBL20115791 | 0.81 | SCN9A (0.57) | SCN9ACYP3A4SCN8A | |
| SCHEMBL20115569 | 0.80 | SCN9A (0.41) | SCN9ACYP3A4SCN8A | |
| SCHEMBL20115793 | 0.79 | SCN9A (0.37) | SCN9ACYP3A4SCN8ASCN3A | |
| SCHEMBL20182630 | 0.76 | SCN9A (0.48) | SCN9ACYP3A4 | |
| SCHEMBL26761547 | 0.73 | SCN9A (0.45) | SCN9ACYP3A4 | |
| SCHEMBL19634095 | 0.72 | SCN8A (0.43) | SCN9ACYP3A4SCN8A | |
| SCHEMBL23913156 | 0.71 | SCN9A (0.67) | SCN9ACYP3A4 | |
| SCHEMBL20115734 | 0.71 | SCN9A (0.56) | SCN9ACYP3A4SCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532462-B1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2018081384-A1 | ACYL SULFONAMIDE NAV1.7 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-03 | — | — | WO | disclosed |