⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18123279 | 0.78 | ALDH1A1 (0.32) | — | |
| SCHEMBL20109902 | 0.77 | ALDH1A1 (0.34) | — | |
| SCHEMBL10594010 | 0.61 | — | — | |
| SCHEMBL18446 | 0.60 | ALDH1A1 (0.53) | — | |
| SCHEMBL497771 | 0.58 | ALDH1A1 (0.40) | — | |
| SCHEMBL6847856 | 0.58 | ALDH1A1 (0.36) | — | |
| SCHEMBL15353618 | 0.58 | HCAR2 (0.50) | — | |
| SCHEMBL6824967 | 0.57 | ALDH1A1 (0.48) | — | |
| SCHEMBL10386529 | 0.57 | ALDH1A1 (0.39) | — | |
| SCHEMBL30031260 | 0.57 | ALDH1A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407444-B2 | Alpha-amino pateamine A derivatives and methods for treating chronic lymphocytic leukemia | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180118764-A1 | ALPHA-AMINO PATEAMINE A DERIVATIVES AND METHODS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2018-05-03 | — | — | US | disclosed |