Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | IDE | P14735 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011561 | 1.00 | APP (0.56) | APPALDH1A1MEN1KMT2APSMD14 | |
| SCHEMBL26382501 | 1.00 | APP (0.56) | APPALDH1A1MEN1KMT2APSMD14 | |
| SCHEMBL2011560 | 1.00 | APP (0.56) | APPALDH1A1MEN1KMT2APSMD14 | |
| SCHEMBL12633780 | 0.97 | APP (0.53) | APPALDH1A1MEN1KMT2APSMD14 | |
| SCHEMBL14701202 | 0.91 | MEN1 (0.62) | APPALDH1A1MEN1KMT2APSMD14 | |
| SCHEMBL14129149 | 0.91 | MEN1 (0.57) | APPALDH1A1MEN1KMT2APSMD14 | |
| SCHEMBL12633779 | 0.88 | ALDH1A1 (0.59) | APPALDH1A1MEN1KMT2ADNM1 | |
| SCHEMBL2011668 | 0.88 | ALDH1A1 (0.59) | APPALDH1A1MEN1KMT2ADNM1 | |
| SCHEMBL2011667 | 0.88 | ALDH1A1 (0.59) | APPALDH1A1MEN1KMT2ADNM1 | |
| SCHEMBL14129172 | 0.87 | MEN1 (0.54) | APPALDH1A1MEN1KMT2APSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170315137-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-02 | — | — | US | disclosed |
| US-9551722-B2 | Amyloid binding agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150177262-A1 | AMYLOID BINDING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| EP-2509940-B1 | AMYLOID BINDING AGENTS | UNIV CALIFORNIA (US) | 2015-06-10 | — | — | EP | disclosed |
| US-8940918-B2 | Amyloid binding agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-01-27 | — | — | US | disclosed |
| US-20120302603-A1 | AMYLOID BINDING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-29 | — | — | US | disclosed |
| EP-2509940-A2 | AMYLOID BINDING AGENTS | The Regents of the University of California (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072257-A2 | AMYLOID BINDING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302603-A1 | AMYLOID BINDING AGENTS | APP, APBA1, PSEN1 | APP 1/4885ALDH1A1 3897/4885MEN1 3763/4885 |
| US-20170315137-A1 | AMYLOID BINDING AGENTS | APBA1, APP, PSEN1 | APP 2/4885ALDH1A1 4267/4885MEN1 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.