SCHEMBL20116267 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	GRM5	P41594	2/20	0.39

▸	LMNA	P02545	2/20	0.39

▸	ALDH1A1	P00352	1/20	0.39

▸	POLB	P06746	1/20	0.39

▸	CYP3A4	P08684	1/20	0.39

▸	MAPT	P10636	1/20	0.39

▸	CYP2C9	P11712	1/20	0.39

▸	CYP2C19	P33261	1/20	0.39

▸	HTT	P42858	1/20	0.39

▸	SMN1; SMN2	Q16637	1/20	0.39

▸	NPSR1	Q6W5P4	1/20	0.39

▸	SMO	Q99835	3/20	0.38

▸	ALOX15	P16050	1/20	0.37

▸	TSHR	P16473	1/20	0.37

▸	MAPK1	P28482	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20116719	0.90	GRM5 (0.42)	GRM5ALDH1A1POLBSMN1; SMN2SMO
SCHEMBL20676644	0.90	GRM5 (0.42)	GRM5ALDH1A1POLBSMN1; SMN2SMO
SCHEMBL20116709	0.90	GRM5 (0.42)	GRM5ALDH1A1POLBSMN1; SMN2SMO
SCHEMBL20676307	0.89	GRM5 (0.39)	GRM5LMNAALDH1A1POLBCYP3A4
SCHEMBL20116743	0.82	LMNA (0.52)	LMNAALDH1A1POLBCYP3A4MAPT
SCHEMBL20676643	0.81	GRM5 (0.50)	GRM5
SCHEMBL20116269	0.79	GRM5 (0.42)	GRM5LMNAMAPTHTTSMN1; SMN2
SCHEMBL20676702	0.79	GRM5 (0.42)	GRM5LMNAALDH1A1POLBSMN1; SMN2
SCHEMBL20116359	0.79	GRM5 (0.42)	GRM5LMNAALDH1A1POLBSMN1; SMN2
SCHEMBL20116351	0.79	GRM5 (0.42)	GRM5LMNAALDH1A1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018081167-A1	COMPOUNDS AND USES THEREOF	YUMANITY THERAPEUTICS (US)	2018-05-03	—	—	WO	disclosed