Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL940867 | 0.91 | KMT2A (0.43) | ADORA2AADORA1CLK4DYRK1AMAPT | |
| SCHEMBL5224949 | 0.89 | ADORA3 (0.48) | ADORA2AADORA1CLK4MAPTTP53 | |
| SCHEMBL5319229 | 0.89 | MAPT (0.42) | ADORA2AADORA1CLK4DYRK1AMAPT | |
| SCHEMBL940803 | 0.89 | ADORA2A (0.41) | ADORA2AADORA1CLK4DYRK1AMAPT | |
| SCHEMBL939986 | 0.88 | THRB (0.44) | ADORA2AADORA1CLK4DYRK1AMAPT | |
| SCHEMBL940828 | 0.88 | MAPT (0.43) | ADORA2AADORA1CLK4DYRK1AMAPT | |
| SCHEMBL2012739 | 0.88 | ADORA2A (0.47) | ADORA2AADORA1MAPTTP53LMNA | |
| SCHEMBL941318 | 0.87 | MAPT (0.42) | ADORA2AADORA1CLK4DYRK1AMAPT | |
| SCHEMBL940680 | 0.86 | ADORA2A (0.39) | ADORA2AADORA1CLK4DYRK1AMAPT | |
| SCHEMBL942101 | 0.86 | KMT2A (0.39) | ADORA2AADORA1CLK4DYRK1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964731-B2 | Isotopically marked quinoline derivatives as adenosin A3 receptor ligands | SANOFI-AVENTIS (FR) | 2011-06-21 | — | — | US | disclosed |
| EP-1814857-B1 | ISOTOPICALLY MARKED QUINOLINE DERIVATIVES AS ADENOSIN A3 RECEPTOR LIGANDS | SANOFI AVENTIS (FR) | 2010-09-01 | — | — | EP | disclosed |
| US-20080027225-A1 | ISOTOPICALLY MARKED QUINOLINE DERIVATIVES AS ADENOSIN A3 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2008-01-31 | — | — | US | disclosed |
| EP-1814857-A1 | ISOTOPICALLY MARKED QUINOLINE DERIVATIVES AS ADENOSIN A3 RECEPTOR LIGANDS | Sanofi-Aventis (FR) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006051341-A1 | ISOTOPICALLY MARKED QUINOLINE DERIVATIVES AS ADENOSIN A3 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027225-A1 | ISOTOPICALLY MARKED QUINOLINE DERIVATIVES AS ADENOSIN A3 RECEPTOR LIGANDS | ACKR3, ADORA3, CIAPIN1 | ADORA2A 8/4885ADORA1 28/4885CLK4 2922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.