Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20676311 | 0.96 | TBK1 (0.45) | TBK1USP7USP30SMN1; SMN2ALDH1A1 | |
| SCHEMBL20676726 | 0.94 | TBK1 (0.44) | TBK1USP7USP30SMN1; SMN2ALDH1A1 | |
| SCHEMBL22358410 | 0.90 | TBK1 (0.43) | TBK1USP7USP30SMN1; SMN2ALDH1A1 | |
| SCHEMBL20116089 | 0.88 | SMO (0.42) | TBK1USP7USP30SMN1; SMN2ALDH1A1 | |
| SCHEMBL20117073 | 0.87 | USP7 (0.40) | TBK1USP7USP30SMN1; SMN2ALDH1A1 | |
| SCHEMBL20676660 | 0.87 | USP7 (0.41) | TBK1USP7USP30SMN1; SMN2ALDH1A1 | |
| SCHEMBL20116423 | 0.87 | FASN (0.43) | TBK1USP7USP30SMN1; SMN2HTT | |
| SCHEMBL20116305 | 0.87 | USP7 (0.41) | TBK1USP7USP30SMN1; SMN2ALDH1A1 | |
| SCHEMBL20116522 | 0.87 | USP7 (0.41) | TBK1USP7USP30SMN1; SMN2HTT | |
| SCHEMBL20676577 | 0.87 | TBK1 (0.39) | TBK1USP7USP30GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11873298-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2024-01-16 | — | — | US | disclosed |
| US-11873298-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2024-01-16 | — | — | US | disclosed |
| US-20200262828-A1 | COMPOUNDS AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-20 | — | — | US | disclosed |
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11873298-B2 | Compounds and uses thereof | NLN, ACHE, CLN6 | TBK1 3534/4885USP7 4265/4885USP30 3526/4885 |
| US-20200262828-A1 | COMPOUNDS AND USES THEREOF | NLN, ACHE, CLN6 | TBK1 3534/4885USP7 4265/4885USP30 3526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.