Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 3/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20676395 | 0.79 | CHEK1 (0.40) | CHEK1LMNACYP1A2CYP3A4GRM5 | |
| SCHEMBL20117027 | 0.78 | PDE4A (0.42) | CHEK1SRCLMNACTSSKDM4E | |
| SCHEMBL21749932 | 0.78 | PDE4A (0.43) | CHEK1SRCLMNAKDM4EALDH1A1 | |
| SCHEMBL21045855 | 0.75 | CHEK1 (0.40) | CHEK1LMNACYP1A2CYP3A4GRM5 | |
| SCHEMBL30439920 | 0.75 | CHEK1 (0.40) | CHEK1LMNACYP1A2CYP3A4GRM5 | |
| SCHEMBL29040356 | 0.74 | KDM4E (0.38) | CHEK1CYP1A2GRM5CTSSHSD17B10 | |
| SCHEMBL20929469 | 0.72 | JAK2 (0.40) | CHEK1SRC | |
| SCHEMBL21045740 | 0.71 | LTA4H (0.47) | CHEK1CTSSGAASLC6A2SLC6A4 | |
| SCHEMBL30439893 | 0.71 | LTA4H (0.47) | CHEK1CTSSGAASLC6A2SLC6A4 | |
| SCHEMBL21045796 | 0.70 | AR (0.44) | CHEK1CYP1A2CYP3A4CTSSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |