Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20117305 | 0.83 | NOTUM (0.43) | CYP1A2KMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL22358039 | 0.83 | PDE10A (0.34) | KMT2AMEN1NOTUMALDH1A1MAPT | |
| SCHEMBL20116576 | 0.78 | CYP1A2 (0.41) | CYP1A2KMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL13607533 | 0.73 | NOTUM (0.44) | CYP1A2KMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL422734 | 0.70 | MAPT (0.63) | CYP1A2KMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL12730005 | 0.69 | CYP1A2 (0.41) | CYP1A2KMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL25097119 | 0.68 | CYP1A2 (0.45) | CYP1A2KMT2AMEN1ALDH1A1NQO2 | |
| SCHEMBL28457711 | 0.67 | HDAC8 (0.37) | CYP1A2KMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL19763359 | 0.66 | NPC1 (0.66) | CYP1A2KMT2AMEN1NOTUMALDH1A1 | |
| SCHEMBL13607690 | 0.66 | KDM4E (0.42) | CYP1A2KMT2AMEN1ALDH1A1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |