Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12730005 | 0.85 | CYP1A2 (0.41) | NOTUMCYP1A2ALDH1A1NQO2CYP2A6 | |
| SCHEMBL20116576 | 0.84 | CYP1A2 (0.41) | NOTUMCYP1A2ALDH1A1NQO2CYP2A6 | |
| SCHEMBL20116579 | 0.83 | CYP1A2 (0.38) | NOTUMCYP1A2ALDH1A1NQO2CYP2A6 | |
| SCHEMBL29190597 | 0.80 | KDM4E (0.61) | NOTUMALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL13677502 | 0.80 | NOTUM (0.40) | NOTUMALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL16595800 | 0.80 | NOTUM (0.40) | NOTUMCYP1A2ALDH1A1CYP2A6MAPT | |
| SCHEMBL30995482 | 0.80 | NOTUM (0.40) | NOTUMALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL12730004 | 0.77 | NOTUM (0.41) | NOTUMCYP1A2ALDH1A1CYP2A6MAPT | |
| SCHEMBL12269133 | 0.77 | NOTUM (0.39) | NOTUMALDH1A1MAPTNPC1NFKB1 | |
| SCHEMBL15723847 | 0.77 | NOTUM (0.40) | NOTUMCYP1A2ALDH1A1NQO2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |