Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20117305 | 0.84 | NOTUM (0.43) | CYP1A2ALDH1A1NQO2CYP2A6KMT2A | |
| SCHEMBL20025158 | 0.79 | NPC1 (0.35) | ALDH1A1HDAC4KMT2AMAPTMEN1 | |
| SCHEMBL16132751 | 0.79 | BACE1 (0.39) | CYP1A2ALDH1A1HDAC4CYP2A6KMT2A | |
| SCHEMBL15910725 | 0.79 | KDM4E (0.56) | ALDH1A1HDAC4KMT2AMAPTMEN1 | |
| SCHEMBL20116579 | 0.78 | CYP1A2 (0.38) | CYP1A2ALDH1A1NQO2CYP2A6KMT2A | |
| SCHEMBL29602706 | 0.73 | HDAC8 (0.44) | ALDH1A1NQO2HDAC4MAPTKDM4E | |
| SCHEMBL422734 | 0.73 | MAPT (0.63) | CYP1A2ALDH1A1NQO2CYP2A6KMT2A | |
| SCHEMBL30147529 | 0.72 | PLK1 (0.43) | HDAC4SMN1; SMN2SYK | |
| SCHEMBL25097119 | 0.72 | CYP1A2 (0.45) | CYP1A2ALDH1A1NQO2CYP2A6KMT2A | |
| SCHEMBL24873712 | 0.71 | LPL (0.40) | HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |