Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116813 | 0.92 | NR1H4 (0.43) | NR1H4HTR4SMN1; SMN2LMNATSHR | |
| SCHEMBL20676461 | 0.90 | NR1H4 (0.42) | NR1H4HTR4SMN1; SMN2LMNATSHR | |
| SCHEMBL20116507 | 0.86 | NR1H4 (0.45) | NR1H4HTR4SMN1; SMN2LMNATSHR | |
| SCHEMBL20116846 | 0.86 | NR1H4 (0.45) | NR1H4HTR4SMN1; SMN2LMNATSHR | |
| SCHEMBL20117198 | 0.86 | NPC1 (0.54) | NR1H4HTR4SMN1; SMN2LMNANPC1 | |
| SCHEMBL20116695 | 0.85 | GRM5 (0.35) | NR1H4HTR4GRM5PTGER3 | |
| SCHEMBL22357882 | 0.84 | SMN1; SMN2 (0.54) | NR1H4SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL22357937 | 0.84 | LMNA (0.47) | NR1H4SMN1; SMN2LMNATSHRSMO | |
| SCHEMBL22357930 | 0.84 | NR1H4 (0.58) | NR1H4HTR4NPC1RAB9AGRM5 | |
| SCHEMBL20116409 | 0.84 | GRM5 (0.43) | NR1H4HTR4SMN1; SMN2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2018081167-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2018-05-03 | — | — | WO | disclosed |